RAVICTI HCP

Important information

  • Of the 16 pediatric patients less than 2 months of age in a 24-month, uncontrolled, open-label study, 5 patients (31%) reported a total of 7 hyperammonemic crises.1
  • Of the 17 pediatric patients 2 months to less than 2 years of age in 3 open-label studies, 7 patients (41%) reported a total of 11 hyperammonemic crises.1
  • Of the 26 pediatric patients 6 to 17 years of age in two 12-month studies of RAVICTI, 5 patients (19%) reported a total of 5 hyperammonemic crises.1
  • Of 51 adult patients in a 12-month study of RAVICTI, 7 patients (14%) reported a total of 10 hyperammonemic crises.1

aIn uncontrolled, open-label, extension clinical trials, mean blood ammonia levels were controlled over at least 12 months in all age groups tested.1

bSix uncontrolled, open-label studies were conducted to assess monthly ammonia control and hyperammonemic crises in patients with urea cycle disorders (UCDs): 16 pediatric patients less than 2 months of age, with 9 patients completing 24 months of treatment; 17 pediatric patients 2 months to less than 2 years of age, with 6 patients completing 12 months of treatment; 26 pediatric patients 6 to 17 years of age over a 12-month period; and 51 adults over a 12-month period.1

RAVICTI: Effective, long-term ammonia control with convenient dosing1,c

RAVICTI is contraindicated in patients with known hypersensitivity to phenylbutyrate.1

cIn uncontrolled, open-label, extension clinical trials, mean blood ammonia levels were controlled over at least 12 months in all age groups tested.1

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Calculate the appropriate starting dose for treatment-naïve patients, quickly convert the dosage from NaPBA to RAVICTI, and optimize the RAVICTI dosage.

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With this test, you can determine your patient's plasma PAA:PAGN ratio and urinary PAGN level.

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References:  1. RAVICTI [package insert]. Lake Forest, IL: Horizon Pharma USA, Inc.; 2018.  2. Diaz GA, Krivitzky LS, Mokhtarani M, et al. Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate. Hepatology 2013;57(6):2171-2179. doi:10.1002/hep.26058.