Horizon By Your Side (HBYS) is a support program for patients prescribed RAVICTI. Our dedicated team partners with your patient to provide nonclinical personalized support so they can start and continue treatment as you prescribe.
CONNECT: Your patient will be connected to one person dedicated to partnering with them throughout their treatment experience
COORDINATE: Your patient will receive educational support on insurance, financial assistance options, important appointment-related information, and more
CHAMPION: Your patient’s dedicated partner will empower them to be confident self-advocates for maintaining treatment goals
Call 1-855-UCD-SUPT Monday–Friday 9 AM–8 PM (EST)
Email us at
UCDSupportHBYS@horizontherapeutics.com
The authorization journey may be different for each of your patients, but the Horizon By Your Side team will help you navigate the unique experience. The team at Horizon By Your Side can help identify coverage policies early in the access process to help ensure maximum efficiency.
A PAL provides dedicated, one-on-one support for your patient. The PAL works directly with your patient to provide nonmedical support upon enrollment and educate your patient about the insurance process and accessing treatment so they can focus less on RAVICTI cost and more on their treatment.
A Amgen Case Manager can help healthcare providers to understand their patients’ benefits and unique access solutions. A Case Manager assigned to your patients may also be in touch with your office to make sure important insurance information is properly shared.
Use this form for authorization to use or provide patient-protected health information.
A Spanish-language form for authorization to use or provide patient-protected information.
Directions for taking RAVICTI by mouth.
Directions for taking RAVICTI by mouth.
View video transcriptWelcome to the RAVICTI® (glycerol phenylbutyrate) Oral Liquid instructional dosing video.
In this video you will see step-by- step instructions for the oral administration of RAVICTI for you or your child.
Use for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used for long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI should be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone. RAVICTI must be used along with a low-protein diet and in some cases, dietary supplements.
RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crisis) in people with UCDs.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
Please listen to the RAVICTI Important Safety Information at the end of this video. For additional important safety information, see the Medication Guide at RAVICTI.com and discuss with your doctor.
This video is intended to complement the instructions you have already received from your doctor. Always take RAVICTI exactly as directed by your doctor.
Do not mix RAVICTI with formula or any other liquids.
Now, let’s get started.
Your RAVICTI shipment includes a 25-mL bottle of RAVICTI, a blue AdaptaCap® Bottle Adapter, and an oral dosing syringe.
When dosing RAVICTI, be sure to use the oral dosing syringe provided with the product.
First, remove the childproof cap on the RAVICTI bottle. To do that, push down on the cap while twisting it to the left.
Then, attach the blue AdaptaCap® Bottle Adapter onto the bottle. Put it on top of the bottle and twist it to the right.
Make sure it is secured tightly on the bottle.
While holding the RAVICTI bottle securely, place the tip of the oral dosing syringe into the AdaptaCap®Bottle Adapter.
Turn the bottle upside down with the oral dosing syringe still inserted.
Now you’re ready to fill the oral dosing syringe with RAVICTI.
Get the medicine into the oral dosing syringe by pulling the plunger back slowly. Pulling slowly will help avoid large air bubbles from forming in the medicine.
Pull the plunger back until the first line of the black rubber stopper is even with the dosing mark. The dosing marks are on the barrel of the oral dosing syringe. Match the dosing mark with the amount of medicine prescribed by your doctor.
Then, turn the bottle upright again.
If there are large air bubbles, push the medicine back into the bottle. Do this slowly.
Then draw up the medicine again.
Once you have your oral dosing syringe ready, place it into the mouth. Push the plunger to squirt the medicine directly into the mouth.
Make sure all of the medicine is pushed out of the oral dosing syringe and swallowed.
Put the cap on the oral dosing syringe.
Drink liquid or eat some food right after taking RAVICTI.
This helps ensure that all of the medicine is swallowed.
Close the tab on the AdaptaCap® Bottle Adapter.
Make sure it’s closed tightly.
You can use 1 oral dosing syringe and 1 blue AdaptaCap® Bottle Adapter for all doses each day. You can also choose to use a new oral dosing syringe with each dose. Do not rinse the AdaptaCap® Bottle Adapter or oral dosing syringe between doses.
After the last dose of the day, dispose of the oral dosing syringe.
If you take too much RAVICTI, call your doctor or go to the nearest hospital emergency room right away.
You should consult your physician if you have missed a dose of RAVICTI.
Do not mix RAVICTI with formula or any other liquids.
Directions for taking RAVICTI by nasogastric or G-tube.
Directions for taking RAVICTI by nasogastric or G-tube.
View video transcriptWelcome to the RAVICTI® (glycerol phenylbutyrate) Oral Liquid instructional dosing video.
In this video, you will see step-by-step instructions for administration of RAVICTI if you or your child have a nasogastric or gastrostomy feeding tube.
If you can swallow liquids, it is recommended you take RAVICTI by mouth.
Use for RAVICTI® (glycerol phenylbutyrate) Oral Liquid
RAVICTI is a prescription medicine used for long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD). RAVICTI should be used if the UCD cannot be managed with a low-protein diet and dietary supplements alone. RAVICTI must be used along with a low-protein diet and in some cases, dietary supplements.
RAVICTI is not used to treat extremely high levels of ammonia in the blood (hyperammonemic crisis) in people with UCDs.
.
It is not known if RAVICTI is safe and effective for the treatment of N-acetylglutamate synthase (NAGS) deficiency.
Please listen to the RAVICTI Important Safety Information at the end of this video. For additional important safety information, see the Medication Guide at RAVICTI.com and discuss with your doctor.
This video is intended to complement the instructions you have already received from your doctor. Always take RAVICTI exactly as directed by your doctor.
Do not mix RAVICTI with formula or any other liquids.
Now, let’s get started.
Your RAVICTI shipment includes: a 25-mL bottle of RAVICTI, a blue AdaptaCap® Bottle Adapter, and an oral dosing syringe.
When dosing RAVICTI, be sure to use the oral dosing syringe provided with the product.
First, remove the childproof cap on the RAVICTI bottle. To do that, push down on the cap while twisting it to the left.
Then, attach the blue AdaptaCap® Bottle Adapter onto the bottle. Put it on top of the bottle and twist it to the right.
Make sure it is secured tightly on the bottle.
While holding the RAVICTI bottle securely, place the tip of the oral dosing syringe into the AdaptaCap® Bottle Adapter.
Turn the bottle upside down with the oral dosing syringe still inserted.
Now you’re ready to fill the oral dosing syringe with RAVICTI.
Get the medicine into the oral dosing syringe by pulling the plunger back slowly. Pulling slowly will help avoid large air bubbles from forming in the medicine.
Pull the plunger back until the first line of the black rubber stopper is even with the dosing mark. The dosing marks are on the barrel of the oral dosing syringe. Match the dosing mark with the amount of medicine prescribed by your doctor.
Then, turn the bottle upright again.
If there are large air bubbles, push the medicine back into the bottle. Do this slowly.
Then draw up the medicine again.
Next, place the tip of the oral dosing syringe into the smaller port of the feeding tube. The smaller port of the nasogastric or gastrostomy feeding tube is used for medicine. Ask your doctor if you are not sure which port to use.
Using the plunger of the oral dosing syringe, slowly and carefully push RAVICTI into the feeding tube. Make sure all of the medicine is pushed out of the oral dosing syringe.
After you have pushed all of the RAVICTI into the feeding tube, remove the oral dosing syringe, put the cap on, and set it aside.
Close the tab on the AdaptaCap® Bottle Adapter. Make sure it’s closed tightly.
Use a separate large syringe to flush water into the feeding tube. A large syringe can be found in the box containing your feeding tube.
Make sure all of the water or formula drains through the feeding tube.
You can use 1 oral dosing syringe and 1 blue AdaptaCap® Bottle Adapter for all doses each day. You can also choose to use a new oral dosing syringe with each dose. Do not rinse the AdaptaCap® Bottle Adapter or oral dosing syringe between doses.
After the last dose of the day, dispose of the oral dosing syringe.
If you take too much RAVICTI, call your doctor or go to the nearest hospital emergency room right away.
You should consult your physician if you have missed a dose of RAVICTI.
For patients who require a volume of less than 1 mL per dose via nasogastric or gastrostomy tube, the delivered dosage may be less than anticipated due to adherence of RAVICTI to the plastic tubing. Therefore, these patients should be closely monitored using ammonia levels following initiation of RAVICTI dosing or dosage adjustments.
UCD Mentors are real patients and caregivers who understand what it means to live with a UCD. UCD Mentors are ready to connect with patients, share their experiences, and answer questions.
Your patients may be interested in learning more about independent organizations that are dedicated to improving the lives of patients with UCDs through support, education, advocacy, and research.
Locate a specialist experienced in
treating patients with UCD near
you or your patient.
Determine your patient’s
plasma PAGN ratio and urinary
PAGN level.
Access resources for your practice
to help in the management
of UCDs.
RAVICTI (glycerol phenylbutyrate) Oral Liquid is indicated for use as a nitrogen-binding agent for chronic management of patients with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or supplementation alone. RAVICTI must be used with dietary protein restriction and, in some cases, dietary supplements (e.g. essential amino acids, arginine, citrulline, protein-free calorie supplements).
The most common adverse reactions reported in clinical trials (at least 10% of patients) were:
Please see Full Prescribing Information.
RAVICTI (glycerol phenylbutyrate) Oral Liquid is indicated for use as a nitrogen-binding agent for chronic management of patients with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or supplementation alone. RAVICTI must be used with dietary protein restriction and, in some cases, dietary supplements (e.g. essential amino acids, arginine, citrulline, protein-free calorie supplements).
The most common adverse reactions reported in clinical trials (at least 10% of patients) were:
Please see Full Prescribing Information.
